Gene information
Official symbol F2
Official full name coagulation factor II, thrombin
Gene type protein-coding gene
Chromosome11p11.2
Gene familyReceptor ligands; Gla domain containing; Complement system regulators and receptors
Resources
Entrez Gene 2147
HGNC HGNC:3535
Ensembl ENSG00000180210
Vega OTTHUMG00000150344
UCSC uc001ndf.5
GO terms: 154 records
GO Description Category LogP Number of genes Detail
GO:0001530 lipopolysaccharide binding GO Molecular Functions -6.94413823 11 More
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001906 cell killing GO Biological Processes -7.45870005 11 More
GO:0001909 leukocyte mediated cytotoxicity GO Biological Processes -5.30042050 7 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002444 myeloid leukocyte mediated immunity GO Biological Processes -7.71730059 9 More
GO:0002446 neutrophil mediated immunity GO Biological Processes -8.04833674 7 More
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0005796 Golgi lumen GO Cellular Components -14.6918478 18 More
GO:0006873 cellular ion homeostasis GO Biological Processes -10.3574947 26 More
GO:0006874 cellular calcium ion homeostasis GO Biological Processes -8.17100062 15 More
GO:0006875 cellular metal ion homeostasis GO Biological Processes -10.3879696 23 More
GO:0006953 acute-phase response GO Biological Processes -24.9631834 19 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008277 regulation of G protein-coupled receptor signaling pathway GO Biological Processes -5.69311965 11 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0008360 regulation of cell shape GO Biological Processes -5.20319448 20 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010543 regulation of platelet activation GO Biological Processes -12.2843439 12 More
GO:0010544 negative regulation of platelet activation GO Biological Processes -8.56314160 7 More
GO:0010712 regulation of collagen metabolic process GO Biological Processes -14.4967625 19 More
GO:0010714 positive regulation of collagen metabolic process GO Biological Processes -7.35623750 7 More
GO:0010721 negative regulation of cell development GO Biological Processes -6.74707916 25 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0014013 regulation of gliogenesis GO Biological Processes -13.3514185 26 More
GO:0014014 negative regulation of gliogenesis GO Biological Processes -4.38480829 9 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0019730 antimicrobial humoral response GO Biological Processes -11.7829906 16 More
GO:0022604 regulation of cell morphogenesis GO Biological Processes -5.63620747 32 More
GO:0030003 cellular cation homeostasis GO Biological Processes -9.22969208 24 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030168 platelet activation GO Biological Processes -17.9354931 20 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030194 positive regulation of blood coagulation GO Biological Processes -18.9359595 14 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0030307 positive regulation of cell growth GO Biological Processes -13.7154299 34 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032965 regulation of collagen biosynthetic process GO Biological Processes -13.1192794 17 More
GO:0032967 positive regulation of collagen biosynthetic process GO Biological Processes -7.48167444 7 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0034767 positive regulation of ion transmembrane transport GO Biological Processes -11.2867591 18 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042730 fibrinolysis GO Biological Processes -16.7830831 11 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043550 regulation of lipid kinase activity GO Biological Processes -3.76907414 6 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045685 regulation of glial cell differentiation GO Biological Processes -7.97684638 17 More
GO:0045686 negative regulation of glial cell differentiation GO Biological Processes -3.12309097 6 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0046425 regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.5317026 20 More
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.8890337 15 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048710 regulation of astrocyte differentiation GO Biological Processes -5.46031079 9 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050768 negative regulation of neurogenesis GO Biological Processes -6.01402466 11 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050820 positive regulation of coagulation GO Biological Processes -18.6547980 14 More
GO:0050829 defense response to Gram-negative bacterium GO Biological Processes -15.0142277 17 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051279 regulation of release of sequestered calcium ion into cytosol GO Biological Processes -5.25087734 14 More
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO Biological Processes -3.97244449 5 More
GO:0051282 regulation of sequestering of calcium ion GO Biological Processes -7.93009971 22 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051480 regulation of cytosolic calcium ion concentration GO Biological Processes -1.62331101 3 More
GO:0051702 biological process involved in interaction with symbiont GO Biological Processes -12.570571 16 More
GO:0051873 killing by host of symbiont cells GO Biological Processes -7.35623750 7 More
GO:0051917 regulation of fibrinolysis GO Biological Processes -20.6622986 13 More
GO:0051918 negative regulation of fibrinolysis GO Biological Processes -14.1555780 9 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051928 positive regulation of calcium ion transport GO Biological Processes -8.94961635 14 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051961 negative regulation of nervous system development GO Biological Processes -6.75305746 12 More
GO:0055065 metal ion homeostasis GO Biological Processes -12.9426258 29 More
GO:0055074 calcium ion homeostasis GO Biological Processes -10.3600555 19 More
GO:0055080 cation homeostasis GO Biological Processes -11.5718912 30 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide GO Biological Processes -7.52692728 10 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070053 thrombospondin receptor activity GO Molecular Functions -5.05559485 3 More
GO:0070942 neutrophil mediated cytotoxicity GO Biological Processes -5.46227840 4 More
GO:0070943 neutrophil-mediated killing of symbiont cell GO Biological Processes -5.46227840 4 More
GO:0070944 neutrophil-mediated killing of bacterium GO Biological Processes -5.46227840 4 More
GO:0070945 neutrophil-mediated killing of gram-negative bacterium GO Biological Processes -5.05559485 3 More
GO:0072503 cellular divalent inorganic cation homeostasis GO Biological Processes -7.40235615 16 More
GO:0072507 divalent inorganic cation homeostasis GO Biological Processes -10.6286093 21 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:0090218 positive regulation of lipid kinase activity GO Biological Processes -5.34310134 6 More
GO:0090303 positive regulation of wound healing GO Biological Processes -15.9447313 16 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098771 inorganic ion homeostasis GO Biological Processes -12.1048319 31 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1900048 positive regulation of hemostasis GO Biological Processes -18.9359595 14 More
GO:1900180 regulation of protein localization to nucleus GO Biological Processes -3.85830967 16 More
GO:1900182 positive regulation of protein localization to nucleus GO Biological Processes -4.19203093 7 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1903036 positive regulation of response to wounding GO Biological Processes -14.4451296 16 More
GO:1903169 regulation of calcium ion transmembrane transport GO Biological Processes -8.80532519 28 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904064 positive regulation of cation transmembrane transport GO Biological Processes -10.8655330 17 More
GO:1904427 positive regulation of calcium ion transmembrane transport GO Biological Processes -4.11465146 13 More
GO:1904892 regulation of receptor signaling pathway via STAT GO Biological Processes -12.9980471 24 More
GO:1904894 positive regulation of receptor signaling pathway via STAT GO Biological Processes -11.2917234 16 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
GO:2000379 positive regulation of reactive oxygen species metabolic process GO Biological Processes -15.0445998 16 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa04072 Phospholipase D signaling pathway KEGG Pathway -3.77257282 17 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04611 Platelet activation KEGG Pathway -14.0379587 18 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa05130 Pathogenic Escherichia coli infection KEGG Pathway -9.84822677 18 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 29 records
Drug name Interaction type Source PMID View
(-)-epicatechin DTC view
anisindione TTD view
apramide a DTC 10978206 view
argatroban inhibitor TdgClinicalTrialChemblInteractionsTTD 103621881022640810608050103536691175235210608016 view
atecegatran metoxil TdgClinicalTrial view
avatrombopag PharmGKBFDA view
azd-8165 TTD view
bivalirudin inhibitor TdgClinicalTrialChemblInteractionsTENDTTD 118338351192379411929334115045701106073211752352 view
bortezomib DTC 20875739 view
chembl1083499 TTD view
chembl586628 DTC view
cianidanol DTC view
cyanidin DTC view
cyanin DTC view
dabigatran inhibitor TdgClinicalTrialChemblInteractionsTENDTTD view
dabigatran etexilate mesylate inhibitor ChemblInteractions view
desirudin inhibitor ChemblInteractions view
enoxaparin TdgClinicalTrial view
heparin TdgClinicalTrialTEND view
lepirudin inhibitor TdgClinicalTrialChemblInteractionsTENDTTD 109126441146743910505536118070121105588911752352 view
lusutrombopag PharmGKBFDA view
melagatran inhibitor TTD view
menadione activator TEND 248493176572956867080292276110469489 view
odiparcil TTD view
pegmusirudin TTD view
quercetin DTC view
silibinin DTC view
tamoxifen PharmGKBFDA view
ximelagatran inhibitor TdgClinicalTrialTEND 1731946917516699176883831753268411752352 view
Related studies: 33 records
Molecular factor Omics type Application Objective MI type Reference
prothrombin proteomics heparin[treatment (pharmacotherapy)] acute myocardial infarction Szczeklik A et al. Arterioscler Thromb. 1992
prothrombin proteomics excellent predictor adverse events[prognosis (bad)] acute ST elevation myocardial infarction Gulba DC et al. Circulation. 1991
prothrombin proteomics thrombolytic agent plus heparin[treatment (pharmacotherapy)] acute myocardial infarction Merlini PA et al. J Am Coll Cardiol. 1995
prothrombin proteomics death[prognosis (bad)] myocardial infarction Agewall S et al. J Hypertens. 1998
prothrombin proteomics cardiovascular adverse events[prognosis (bad)] myocardial infarction Agewall S et al. J Hypertens. 1998
prothrombin proteomics ventricular fibrillation[prognosis (bad)] acute myocardial infarction Elmas E et al. Clin Cardiol. 2006
prothrombin proteomics death;recurrent myocardial infarction;coronary revascularization[prognosis (bad)] acute ST elevation myocardial infarction Ulrich-Mockel NV et al. Biomarkers. 2009
prothrombin proteomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Smid M et al. J Thromb Haemost. 2011
prothrombin proteomics glucose intolerance[prognosis (bad)] acute ST elevation myocardial infarction Knudsen EC et al. J Thromb Haemost. 2011
prothrombin proteomics periodontitis[prognosis (bad)] acute myocardial infarction Mantyla P et al. J Periodontal Res. 2012
prothrombin proteomics thrombolytic agent[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Halvorsen S et al. Thromb Res. 2012
prothrombin proteomics old myocardial infarction[diagnosis] old myocardial infarction Smid M et al. PLoS One. 2013
prothrombin proteomics left ventricular ejection fraction[other] acute ST elevation myocardial infarction Hansen CH et al. Thromb J. 2015
prothrombin proteomics ischemic cardiac events[prognosis (bad)] ST elevation myocardial infarction Silvain J et al. Am J Cardiovasc Drugs. 2018
NM_000506.5:c.*97G>A genomics myocardial infarction[diagnosis] myocardial infarction Rosendaal FR et al. Blood. 1997
NM_000506.5:c.*97G>A genomics myocardial infarction[diagnosis] myocardial infarction Arruda VR et al. Cardiovasc Res. 1998
NM_000506.5:c.*97G>A genomics myocardial infarction[diagnosis] myocardial infarction Franco RF et al. Br J Haematol. 1999
NM_000506.5:c.*97G>A genomics coronary artery stenosis[prognosis (bad)] acute myocardial infarction Van de Water NS et al. J Am Coll Cardiol. 2000
NM_000506.5:c.*97G>A genomics myocardial infarction[diagnosis] myocardial infarction Butt C et al. Blood. 2003
NM_000506.5:c.*97G>A genomics myocardial infarction[diagnosis] myocardial infarction Butt C et al. Blood. 2003
NM_000506.5:c.*97G>A genomics myocardial infarction[diagnosis] myocardial infarction Rallidis LS et al. Thromb Haemost. 2003
NM_000506.5:c.494C>T genomics myocardial infarction[diagnosis] myocardial infarction Hindorff LA et al. Am J Epidemiol. 2006
NM_000506.5:c.*97G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Celik M et al. Saudi Med J. 2008
NM_000506.5:c.*97G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Forte GI et al. Biogerontology. 2011
NM_000506.5:c.*97G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Tomaiuolo R et al. J Transl Med. 2012
NM_000506.5:c.*97G>A genomics myocardial infarction[diagnosis] myocardial infarction Kallel A et al. Biochem Genet. 2016
NM_000506.5:c.*97G>A genomics myocardial infarction[diagnosis] myocardial infarction Kallel A et al. Biochem Genet. 2016
NM_000506.5:c.*97G>A genomics myocardial infarction[diagnosis] myocardial infarction Hmimech W et al. Biomed Rep. 2016
NM_000506.5:c.*97G>A genomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Rallidis LS et al. J Thromb Thrombolysis. 2017
NM_000506.5:c.*97G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Psaty BM et al. Jama. 2001
prothrombin proteomics ischemic cardiac events[prognosis (bad)] acute ST elevation myocardial infarction Scharfstein JS et al. Am J Cardiol. 1996
prothrombin proteomics left ventricular thrombus[prognosis (bad)] acute myocardial infarction Solheim S et al. Thromb J. 2013
thrombin antithrombin complex proteomics ischemic cardiac events[prognosis (bad)] acute ST elevation myocardial infarction Scharfstein JS et al. Am J Cardiol. 1996
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